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Publication

  • Zhenghua Liang, Yaxin Hu, Cheuk Yin Li, Wai Laam Yau, Kaixin Tan, and Yi Kuang. "VPg-based bidirectional synthetic mRNA circuits enable orthogonal protein regulation for high-resolution cell separation" Chemical Communications (2024). [Full text]

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  • Zhenghua Liang, Kaixin Tan, Cheuk Yin Li, and Yi Kuang. "Self-feedback loop-containing synthetic mRNA switches for controlled microRNA sensing" Bioorganic Chemistry (2024). [Full text]

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  • Yaxin Hu, Cheuk Yin Li, Qiuyu Lu, and Yi Kuang. "Multiplex miRNA reporting platform for real-time profiling of living cells." Cell Chemical Biology (2024). [Full text]

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  • Kaixin Tan, Yaxin Hu, Zhenghua Liang, Cheuk Yin Li, Wai Laam Yau, and Yi Kuang. "Dual Input-Controlled Synthetic mRNA Circuit for Bidirectional Protein Expression Regulation." ACS Synthetic Biology (2023). [Full text]

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  • Cheuk Yin Li, Zhenghua Liang, Lejian Liu, and Yi Kuang. "Intracellular Molecules Induced Extracellular Peptide Self‐Assembly for Efficient and Effective In Situ Cell Purification." Angewandte Chemie (2023): e202306533. [Full text]

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  • Cheuk Yin Li, Zhenghua Liang, Yaxin Hu, Hongxia Zhang, Kharis Daniel Setiasabda, Jiawei Li, Shaohua Ma, Xiaojun Xia, Yi Kuang. "Cytidine-containing Tails Robustly Enhance and Prolong Protein Production of Synthetic mRNA In Cell and In Vivo" Molecular Therapy - Nucleic Acids, 2022, [Full text]

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  • Haoran Zhao, Yifan Cheng, Jiawei Li, Jiaqi Zhou, Haowei Yang, Feng Yu, Feihong Yu, Davit Khutsishvili, Zitian Wang, Shengwei Jiang, Kaixin Tan, Yi Kuang, Xinhui Xing, Shaohua Ma. "Droplet-engineered organoids recapitulate parental tissue transcriptome with inter-organoid homogeneity and inter-tumor cell heterogeneity". Fundamental Research, 2022, [Full text]

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  • Qiuyu Lu, Yaxin Hu, Cheuk Yin Li, Yi Kuang. "Aptamer-Array-Guided Protein Assembly Enhances Synthetic mRNA Switch Performance". Angew. Chem. Int. Ed.2022, e202207319.  [Full text] 

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  • Callum J C Parr, Shunsuke Wada, Kenjiro Kotake, Shigetoshi Kameda, Satoshi Matsuura, Souhei Sakashita, Soyoung Park, Hiroshi Sugiyama, Yi Kuang, Hirohide Saito. "N1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells". Nucleic Acids Research. 2020, gkaa070. [Full text]

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  • Kuang Y.; Miki K.; Parr C. J. C.; Hayashi K.; Takei I.; Li J.; Iwasaki M.; Nakagawa M.; Yoshida Y.; Saito H. “Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides” Cell Chem. Bio., 2017, S2451-9456(17)30140. [Full text]

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  • Du X, Zhou J, Wang H, Shi J, Kuang Y, Zeng W, Yang Z, Xu B. “In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells”. Cell Death Dis., 2017,16;8(2): :e2614-2625. [Full text]

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  • Parr CJ, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, Takahashi J, Yamanaka S, Saito H. “MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells”. Sci Rep., 2016,9;6:32532-32546. [Full text]

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  • Zhou, R.; Kuang, Y.; Zhou, J.; Du, X. W.; Li, J.; Shi, J. F.; Haburcak, R.; Xu, B.* “Nanonets Collect Cancer Secretome from Pericellular Space” PLoS One, 2016, 11(4): e0154126. [Full text]

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  • Li, J.; Kuang, Y.; Shi, J. F.; Zhou, J.; Medina, J. E.; Zhou, R.; Yuan, D.; Yang, C. H.; Wang, H. M.; Yang, Z. M.; Liu, J. F.; Dinulescu, D. M. and Xu, B. “Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells” Angew. Chem. Intl. Ed., 2015, 13307-13311. [Full text]

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  • Kuang, Y.; Long, M. J. C.; Zhou, J.; Shi, J. F.; Gao, Y.; Xu, C.; Hedstrom, L.; Xu, B. “Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics” J. Biol. Chem., 2014, 289, 29208-20218. [Full text]

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  • Kuang, Y.; Shi, J. F.; Li, J.; Yuan, D.; Alberti, K. A.; Xu, Q. B.; Xu, B. “Pericellular Hydrogel/Nanonets Inhibit Cancer Cells” Angew. Chem. Intl. Ed., 2014,53, 8104-8107. [Full text]

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  • Kuang, Y.; Du, X. W.; Zhou, J.; Xu, B. “Supramolecular Nanofibrils Inhibit Cancer Progression In Vitro and In Vivo” Adv. Healthcare Mater., 2014, 3, 1217-1221. [Full text]

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  • Kuang, Y.; Gao, Y.; Shi, J. F.; Li, J; Xu, B. “The First Supramolecular Peptidic Hydrogelator Containing Taurine” Chem. Commun., 2014, 50, 2772-2774. [Full text]

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  • Kuang, Y.; Zhou N.; Xu B. “Chapter 2: Biocompatibility of Hydrogelators Based on Small Peptide Derivatives” Hydrogels in Cell-Based Therapies, 2014, 31-47. [Full text]

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  • Kuang Y, Long MJ, Zhou J, Shi J, Gao Y, Xu C, Hedstrom L, Xu B. “Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics”.J Biol Chem., 2014, 17;289(42):29208-18 [Full text]

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  • Zhang Y, Zhou N, Akella S, Kuang Y, Kim D, Schwartz A, Bezpalko M, Foxman BM, Fraden S, Epstein IR, Xu B. Active cross-linkers that lead to active gels.Angew Chem Int Ed Engl., 2013, 25;52(44):11494-8. [Full text]

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  • Li J, Gao Y, Kuang Y, Shi J, Du X, Zhou J, Wang H, Yang Z, Xu B. “Dephosphorylation of D-peptide derivatives to form biofunctional, supramolecular nanofibers/hydrogels and their potential applications for intracellular imaging and intratumoral chemotherapy”.J Am Chem Soc. 2013, 3;135(26):9907-14. [Full text]

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  • Li J, Kuang Y, Shi J, Gao Y, Zhou J, Xu B. “The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels”.Beilstein J Org Chem. 2013 ,10;9:908-17. [Full text]

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  • Zhang Y, Zhang B, Kuang Y, Gao Y, Shi J, Zhang XX, Xu B. “A redox responsive, fluorescent supramolecular metallohydrogel consists of nanofibers with single-molecule width”. J Am Chem Soc. 2013, 3;135(13):5008-11. [Full text]

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  • Yang Z, Kuang Y, Li X, Zhou N, Zhang Y, Xu B. “Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA”. Chem Commun (Camb). 2012 ,25;48(74):9257-9. [Full text]

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  • Li X, Du X, Gao Y, Shi J, Kuang Y, Xu B. “Supramolecular hydrogels formed by the conjugates of nucleobases, Arg-Gly-Asp (RGD) peptides, and glucosamine".Soft Matter. 2012 ,28;8(28):7402-7407. [Full text]

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  • Du X, Li J, Gao Y, Kuang Y, Xu B. “Catalytic dephosphorylation of adenosine monophosphate (AMP) to form supramolecular nanofibers/hydrogels”. Chem Commun (Camb). 2012, 18;48(15):2098-100. [Full text]

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  • Zhang Y, Li N, Delgado J, Gao Y, Kuang Y, Fraden S, Epstein IR, Xu B. “Post-self-assembly cross-linking of molecular nanofibers for oscillatory hydrogels”. Langmuir. 2012,14;28(6):3063-6. [Full text]

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  • Kuang, Y.; Xu, B. “Disruption of the Dynamics of Microtubules and Selective Inhibition of Glioblastoma Cells by Nanofibers of Small Hydrophobic Molecules” Angew. Chem. Intl. Ed., 2013, 52, 6944-6948. [Full text]

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  • Kuang, Y.; Yuan D.; Zhang, Y.; Kao, A., Du, X. W.; Xu, B. “Interactions Between Cellular Proteins and Morphologically Different Nanoscale Aggregates of Small Molecules” RSC Advances, 2013, 3, 7704-7707. [Full text]

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  • Li, J. Y.; Kuang, Y.; Gao, Y.; Du, X. W.; Shi, J. F.; Xu, B. “D-Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Non-steroidal Anti-inflammatory Drug (NSAID)" J. Am. Chem. Soc., 2013, 135, 542-545. [Full text]

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  • Gao, Y.; Kuang, Y.; Du, X. W.; Zhou, J.; Chandran, P.; Horkay, F.; Xu, B. “Imaging Self-assembly Dependent Spatial Distribution of Small Molecules in Cellular Environment” Langmuir, 2013, 29, 15191-15200. [Full text]

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  • Li, X. M.; Kuang, Y.; Xu, B. “Molecular Trinity” for Soft Nanomaterials: Integrating Nucleobases, Amino Acids, and Glycosides to Construct Multifunctional Hydrogelators” Soft Matter, 2012, 10,2801-2806. [Full text]

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  • Kuang, Y.; Gao, Y.; Xu, B. “Supramolecular Hydrogelators of N-terminated Dipeptides Selectively Inhibit Cancer Cells” Chem. Commun., 2011, 47, 12625-12627. [Full text]

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  • Kuang, Y.; Gao, Y.; Shi, J. F.; Lin, H.-C.; Xu, B. “Supramolecular Hydrogels Based on the Epitope of Potassium Ion Channels” Chem. Commun., 2011, 47, 8772-8775.​​ [Full text]

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  • Li X, Kuang Y, Shi J, Gao Y, Lin HC, Xu B. “Multifunctional, biocompatible supramolecular hydrogelators consist only of nucleobase, amino acid, and glycoside”. J Am Chem Soc. 2011,2;133(43):17513-8. [Full text]

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  • Li X, Kuang Y, Lin HC, Gao Y, Shi J, Xu B. “Supramolecular nanofibers and hydrogels of nucleopeptides”. Angew Chem Int Ed Engl. 2011 ,26;50(40):9365-9. [Full text]

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  • Zhang Y, Kuang Y, Gao Y, Xu B. “Versatile small-molecule motifs for self-assembly in water and the formation of biofunctional supramolecular hydrogels”. Langmuir. 2011,18;27(2):529-37. [Full text]

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  • Li X, Li J, Gao Y, Kuang Y, Shi J, Xu B. “Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent”. J Am Chem Soc. 2010 ,22;132(50):17707-9. [Full text]

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  • Li X, Gao Y, Kuang Y, Xu B. “Enzymatic formation of a photoresponsive supramolecular hydrogel”. Chem Commun (Camb). 2010 Aug 7;46(29):5364-6. [Full text]

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  • Ma M, Kuang Y, Gao Y, Zhang Y, Gao P, Xu B. “Aromatic-aromatic interactions induce the self-assembly of pentapeptidic derivatives in water to form nanofibers and supramolecular hydrogels”. J Am Chem Soc. 2010 , 3;132(8):2719-28. [Full text]

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  • Gao Y, Yang Z, Kuang Y, Ma ML, Li J, Zhao F, Xu B. “Enzyme-instructed self-assembly of peptide derivatives to form nanofibers and hydrogels”. Biopolymers. 2010,94(1):19-31. [Full text]

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  • Gao Y, Kuang Y, Guo ZF, Guo Z, Krauss IJ, Xu B. “Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative”.  J. Am. Chem. Soc., 2009, 131, 13576-13577. [Full text]

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  • Liang G, Yang Z, Zhang R, Li L, Fan Y, Kuang Y, Gao Y, Wang T, Lu WW, Xu B. “Supramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivo”. Langmuir. 2009,4;25(15):8419-22. [Full text]

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  • Gao J, Liang G, Cheung JS, Pan Y, Kuang Y, Zhao F, Zhang B, Zhang X, Wu EX, Xu B. “Multifunctional yolk-shell nanoparticles: a potential MRI contrast and anticancer agent”. J Am Chem Soc. 2008,3;130(35):11828-33. [Full text]

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  • Liang G, Xu K, Li L, Wang L, Kuang Y, Yang Z, Xu B. “Using Congo red to report intracellular hydrogelation resulted from self-assembly of small molecules”. Chem Commun (Camb). 2007, 28;(40):4096-8. [Full text]

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  • Gao J, Liang G, Zhang B, Kuang Y, Zhang X, Xu B. “FePt@CoS(2) yolk-shell nanocrystals as a potent agent to kill HeLa cells”. J Am Chem Soc. 2007,7;129(5):1428-33. [Full text]

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